The effect of drug holidays in an animal model of tardive dyskinesia
- PMID: 6779315
- DOI: 10.1007/BF00427654
The effect of drug holidays in an animal model of tardive dyskinesia
Abstract
Intermittent haloperidol treatment in mice increased 3H-spiroperidol binding to the same degree as continual haloperidol feeding. The results do not support the concept that drug holidays can reduce the incidence of tardive dyskinesia.
Similar articles
-
Effects of intermittent haloperidol treatment on dopamine receptor sensitivity in guinea pigs.Psychopharmacology (Berl). 1984;84(1):98-100. doi: 10.1007/BF00432034. Psychopharmacology (Berl). 1984. PMID: 6436898
-
Molindone compared to haloperidol in a guinea-pig model of tardive dyskinesia.Neuropharmacology. 1984 Oct;23(10):1191-4. doi: 10.1016/0028-3908(84)90238-7. Neuropharmacology. 1984. PMID: 6240609
-
Neuroleptic drug-induced dopamine receptor supersensitivity: antagonism by L-prolyl-L-leucyl-glycinamide.Science. 1981 Dec 11;214(4526):1261-2. doi: 10.1126/science.6117947. Science. 1981. PMID: 6117947
-
Animal models of tardive dyskinesia: their use in the search for new treatment methods.Mod Probl Pharmacopsychiatry. 1983;21:5-20. doi: 10.1159/000408479. Mod Probl Pharmacopsychiatry. 1983. PMID: 6140633 Review. No abstract available.
-
Tardive dyskinesia: pathophysiology and animal models.J Clin Psychiatry. 2000;61 Suppl 4:5-9. J Clin Psychiatry. 2000. PMID: 10739324 Review.
Cited by
-
EC50 images reveal reproducible spatial variation in drug affinity across single- and repeat-dose occupancy studies.J Cereb Blood Flow Metab. 2025 Jun 25:271678X251353140. doi: 10.1177/0271678X251353140. Online ahead of print. J Cereb Blood Flow Metab. 2025. PMID: 40562708 Free PMC article.
-
Effects of discontinuous drug administration on the development of dopamine receptor supersensitivity during chronic trifluoperazine or cis-flupenthixol administration to rats.Psychopharmacology (Berl). 1985;86(1-2):228-32. doi: 10.1007/BF00431715. Psychopharmacology (Berl). 1985. PMID: 3927361
-
A depot neuroleptic withdrawal study neurological effects.Psychopharmacology (Berl). 1983;80(2):101-5. doi: 10.1007/BF00427950. Psychopharmacology (Berl). 1983. PMID: 6136059 Clinical Trial.
-
Intermittent and continuous haloperidol regimens produce different types of oral dyskinesias in rats.Psychopharmacology (Berl). 1990;100(3):404-12. doi: 10.1007/BF02244615. Psychopharmacology (Berl). 1990. PMID: 2315437
-
Management of tardive dyskinesia: current update.Drugs. 1982 May;23(5):381-93. doi: 10.2165/00003495-198223050-00003. Drugs. 1982. PMID: 7047137 Review.
References
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources