doi: 10.1007/BF02409407.
Regulation of calcium-binding protein messenger RNA by 1,25-dihydroxycholecalciferol
- PMID: 6780152
- DOI: 10.1007/BF02409407
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Regulation of calcium-binding protein messenger RNA by 1,25-dihydroxycholecalciferol
Calcif Tissue Int.
1981.
Abstract
1,25-Dihydroxycholecalciferol modulates the synthesis of the intestinal calcium-binding protein. To determine if this effect is due to an increase in calcium-binding protein mRNA activity, we measured total cytoplasmic protein-specific mRNA activity from chick intestine in an in vitro wheat germ translation system. 1,25-Dihydroxycholecalciferol enhances calcium-binding protein specific mRNA activity. The sterol does not induce a general increase in mRNA synthesis since the concentration of only a few proteins increased. Thus 1,25-dihydroxycholecalciferol regulates only a subset of genes and specifically affects a transcriptional process involving calcium-binding protein synthesis.
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