Oestradiol and progesterone receptors in the mammary tissue and tumours of female Holtzman rats following 7,12-dimethylbenz(a)anthracene administration
- PMID: 6780953
- DOI: 10.1159/000225527
Oestradiol and progesterone receptors in the mammary tissue and tumours of female Holtzman rats following 7,12-dimethylbenz(a)anthracene administration
Abstract
A single dose of the carcinogen 7,12-dimethylbenz(a)-anthracene (DMBA) when administered to 55-day-old female Holtzman rats did not produce any change in the pattern or amount of oestradiol receptors in the breast tissues, when compared to age-matched control animals. The period of observation extended up to 280 days of age. Following DMBA administration to 102 animals, only 60% developed carcinomas of the breast, of which 59 and 50% were ER- an PgR-positive, respectively. This lower yield of steroid receptor-positive tumours in this strain of rats was also reflected in a very low incidence of regression of tumours to ovariectomy. Plausible explanations for both these findings have been offered.
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