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. 1980 Oct;14(10):1127-31.
doi: 10.1203/00006450-198010000-00008.

Propionate inhibition of succinate:CoA ligase (GDP) and the citric acid cycle in mitochondria

D A Stumpf, J McAfee, J K Parks, L Eguren

Propionate inhibition of succinate:CoA ligase (GDP) and the citric acid cycle in mitochondria

D A Stumpf et al. Pediatr Res. 1980 Oct.

Abstract

Propionate inhibits oxygen consumption by rat liver mitochondria when glutamate, alpha-ketaglutarate, and succinate are substrates. Carnitine prevents this effect. The pattern of inhibition of 14CO2 release from metabolic intermediates indicates citric acid cycle inhibition between succinate:coenzyme A (CoA) ligase (GDP) and malate dehydrogenase. Propionyl CoA is synthesized from propionate in mitochondria. Propionyl CoA is a potent inhibitor of succinate:CoA ligase with positive cooperativity and half half-maximal inhibition at 2 X 10(-4) M propionyl CoA.

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