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. 1980 Dec 15;36(12):1350-1.
doi: 10.1007/BF01960091.

A possible method for improving the efficacy of dapsone

K Prabhakaran, E B Harris, W F Kirchheimer

A possible method for improving the efficacy of dapsone

K Prabhakaran et al. Experientia. .

Abstract

The antileprosy drug dapsone is unable to penetrate intact Mycobacterium leprae in vitro, as determined by its effect on o-diphenoloxidase in the bacilli. When combined with the peptide polylysine, the sulfone drug passes through the bacterial cell membranes, and penetrates the enzyme protein, resulting in a 100% inhibition of its activity.

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