Biochemical studies of bone from diabetic rats and rats bearing transplanted pancreatic islets

Abstract

A comparison of lysozymal enzymes involved in glycosaminoglycan metabolism in cortical bone found significantly increased activity in the presence of streptozotocin-induced diabetes. The presence of transplanted pancreatic islets and restitution of the normal systemic insulin and glucose values did not alter these changes. The enzyme activity of cancellous bone appeared to be even less responsive to diabetic pathology with changes developing only with advancing age.