doi: 10.1038/290372a0.
Aberrant rearrangements contribute significantly to the allelic exclusion of immunoglobulin gene expression
- PMID: 6783959
- DOI: 10.1038/290372a0
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Aberrant rearrangements contribute significantly to the allelic exclusion of immunoglobulin gene expression
Nature.
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Abstract
A study of the organization of light- and heavy-chain immunoglobulin genes in mouse splenic B cells, spleen-derived hybridomas and plasmacytomas has unequivocally demonstrated that aberrant rearrangements are common during normal B-cell development. The results support a probabilistic model for allelic exclusion of immunoglobulin gene expression.
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