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. 1981 Apr 2;290(5805):372-8.
doi: 10.1038/290372a0.

Aberrant rearrangements contribute significantly to the allelic exclusion of immunoglobulin gene expression

C Coleclough, R P Perry, K Karjalainen, M Weigert

Aberrant rearrangements contribute significantly to the allelic exclusion of immunoglobulin gene expression

C Coleclough et al. Nature. .

Abstract

A study of the organization of light- and heavy-chain immunoglobulin genes in mouse splenic B cells, spleen-derived hybridomas and plasmacytomas has unequivocally demonstrated that aberrant rearrangements are common during normal B-cell development. The results support a probabilistic model for allelic exclusion of immunoglobulin gene expression.

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