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. 1981 Mar;41(3):843-5.
doi: 10.1128/aem.41.3.843-845.1981.

Microbial transformations of 7,2-dimethylbenz[a]anthracene

J Wu, L K Wong

Microbial transformations of 7,2-dimethylbenz[a]anthracene

J Wu et al. Appl Environ Microbiol. 1981 Mar.

Abstract

Microbial transformations of 7,12-dimethylbenz[a]anthracene, a carcinogenic polycyclic aromatic hydrocarbon, in cultures of Pseudomonas aeruginosa and Penicillium notatum were studied by high performance liquid chromatographic separation of metabolic fractions followed by gas chromatographic-mass spectrometric analysis of the metabolites. Two methyl-hydroxylated metabolites were identified in each of the incubations. The metabolic activation of the polycyclic aromatic hydrocarbon suggests a possible involvement of microorganisms in environmental carcinogenesis.

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