[Therapy of aminoacid and protein metabolism disturbances in liver disease (author's transl)]

Abstract

1. The role of the liver in synthesis and metabolism of proteins, in the metabolism of certain aminoacids, and in urea synthesis is described. 2. In the liver disease protein synthesis may be reduced. The activity of lysosomal proteases is enhanced during acute hepatitis and in cirrhosis. Diseases of the liver may be associated with various derangements in the metabolic pathways of particular aminoacids. Synthesis of urea is decreased in chronic liver disease. 3. Nutrition for patients with chronic liver disease needs to include sufficient calories and has to be well balanced. Parenteral nutrition and diet in patients with edema and ascites deserves special attention. Dietary treatment of patients with cirrhosis of the liver and impending or already existing hepatic encephalopathy is outlined.