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Clinical Trial
. 1981;73(1):95-6.
doi: 10.1007/BF00431111.

A preliminary double-blind study on the efficacy of carbamazepine in prophylaxis of manic-depressive illness

T Okuma, K Inanaga, S Otsuki, K Sarai, R Takahashi, H Hazama, A Mori, S Watanabe
Clinical Trial

A preliminary double-blind study on the efficacy of carbamazepine in prophylaxis of manic-depressive illness

T Okuma et al. Psychopharmacology (Berl). 1981.

Abstract

A preliminary double-blind controlled study on the prophylactic effect of carbamazepine on recurrent manic-depressive psychotics was conducted with 22 patients using an inert placebo in ten subjects as a control drug. Carbamazepine in the dosage of 200-600 mg was administered for 1 year. Among the 22 carbamazepine subjects, carbamazepine was found to be effective in 60% of the cases and inert placebo in 22.2% (U-test, P less than 0.10). It is suggested that carbamazepine is a useful drug for the prophylaxis of manic-depressive illness.

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References

    1. Psychopharmacology (Berl). 1979;66(3):211-7 - PubMed
    1. Folia Psychiatr Neurol Jpn. 1973;27(4):283-97 - PubMed

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