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. 1981 Feb 1;153(2):269-79.
doi: 10.1084/jem.153.2.269.

A monoclonal antibody that recognizes B cells and B cell precursors in mice

R L Coffman, I L Weissman

A monoclonal antibody that recognizes B cells and B cell precursors in mice

R L Coffman et al. J Exp Med. .

Abstract

The monoclonal antibody, RA3-2C2, appears to be specific for cells within the B cell lineage. This antibody does not recognize thymocytes, peripheral T cells, or nonlymphoid hematopoietic cells in the spleen or bone marrow. Nor does it recognize the pluripotent hematopoietic stem cells, the spleen colony-forming unit, All sIg+ B cells and most plasma cells are RA3-2C2+. In addition, approximately 20% of nucleated bone marrow cells are RA3-2C2+ but sIg-. This population contains B cell precursors that can give rise to sIg+ cells within 2 d in vitro.

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