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Comparative Study
. 1977 May 28;1(6073):1377-9.
doi: 10.1136/bmj.1.6073.1377.

Detection and measurement of fetomaternal haemorrhage: serum alpha-fetoprotein and the Kleihauer technique

E Lachman, S M Hingley, G Bates, A M Ward, C R Stewart, S L Duncan
Comparative Study

Detection and measurement of fetomaternal haemorrhage: serum alpha-fetoprotein and the Kleihauer technique

E Lachman et al. Br Med J. .

Abstract

A raised maternal serum alpha-fetoprotein concentration was taken as an indicator of fetomaternal haemorrhage due to amniocentesis and was used to calculate the volume of the fetal bleed. The alpha-fetoprotein concentration seemed to be a more sensitive and reliable indicator than the established Kleihauer technique and may have further applications in antenatal testing.

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