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. 1981 Apr;11(1-2):94-6.
doi: 10.1007/BF01991467.

New light on the mechanism of action of disodium cromoglycate

R G Alvarez, W Kazimierczak

New light on the mechanism of action of disodium cromoglycate

R G Alvarez et al. Agents Actions. 1981 Apr.

Abstract

Disodium cromoglycate (DSCG) shows a prolonged protective effect against histamine on the smooth muscle of guinea pig ileum. Preventing allergen-induced mediator release from mast cells as well as protection of smooth muscle against mediators already released can both explain a beneficial effect of DSCG in the treatment of bronchial asthma and food allergy. It is believed that disappointing clinical trials with many new anti-allergic drugs, e.g. RS 7540, can be explained by the lack of protective effect on the smooth muscle of target organs.

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