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. 1981;73(4):311-3.
doi: 10.1007/BF00426456.

Amphetamine-, scopolamine- and caffeine-induced locomotor activity following 6-hydroxydopamine lesions of the mesolimbic dopamine system

E M Joyce, G F Koob

Amphetamine-, scopolamine- and caffeine-induced locomotor activity following 6-hydroxydopamine lesions of the mesolimbic dopamine system

E M Joyce et al. Psychopharmacology (Berl). 1981.

Abstract

As previously reported, 6-hydroxydopamine (6-OHDA) lesions to the region of the nucleus accumbens blocked the locomotor activation induced by low doses of d-amphetamine, and produced a supersensitive locomotor response to the dopamine (DA) agonist, apomorphine. This same lesion, however, failed to block the locomotor activation induced by scopolamine or caffeine. These results suggest that scopolamine and caffeine activate locomotion in the rat by acting independently of presynaptic terminals in the mesolimbic DA system.

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References

    1. Eur J Pharmacol. 1976 Nov;40(1):45-56 - PubMed
    1. J Biol Chem. 1962 Apr;237:1244-50 - PubMed
    1. Life Sci. 1974 Apr 16;14(8):1493-500 - PubMed

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