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. 1981 Jul;35(1):17-22.
doi: 10.1016/S0006-3495(81)84770-4.

DNA repair in human fibroblasts treated with a combination of chemicals

F E Ahmed, R B Setlow

DNA repair in human fibroblasts treated with a combination of chemicals

F E Ahmed et al. Biophys J. 1981 Jul.

Abstract

Excision repair of DNA damage was measured by the photolysis of bromodeoxy-uridine incorporated during repair in normal human and xeroderma pigmentosum group C fibroblasts (XP C) treated with a combination of the carcinogens N-acetoxy-2-acetylamino-fluorene (AAAF), and 4-nitroquinoline 1-oxide (4NQO). Repair was additive in normal and XP C cells treated with AAAF plus 4NQO, indicating that there are different rate limiting steps for removal of 4NQO and AAAF lesions.

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