doi: 10.1016/S0006-3495(81)84770-4.
DNA repair in human fibroblasts treated with a combination of chemicals
- PMID: 6789902
- PMCID: PMC1327499
- DOI: 10.1016/S0006-3495(81)84770-4
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DNA repair in human fibroblasts treated with a combination of chemicals
Biophys J.
1981 Jul.
Abstract
Excision repair of DNA damage was measured by the photolysis of bromodeoxy-uridine incorporated during repair in normal human and xeroderma pigmentosum group C fibroblasts (XP C) treated with a combination of the carcinogens N-acetoxy-2-acetylamino-fluorene (AAAF), and 4-nitroquinoline 1-oxide (4NQO). Repair was additive in normal and XP C cells treated with AAAF plus 4NQO, indicating that there are different rate limiting steps for removal of 4NQO and AAAF lesions.
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