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. 1981 Sep 1;154(3):978-82.
doi: 10.1084/jem.154.3.978.

Responder T cells depleted of alloreactive cells react to antigen presented on allogeneic macrophages from nonresponder strains

N Ishii, C N Baxevanis, Z A Nagy, J Klein

Responder T cells depleted of alloreactive cells react to antigen presented on allogeneic macrophages from nonresponder strains

N Ishii et al. J Exp Med. .

Abstract

T cells from strains responder to the antigen poly(Glu40 Ala60) (GA) were depleted of alloreactive cells by bromo-deoxyuridine and light treatment, and were subsequently primed in vitro in GA presented by allogeneic macrophages from nonresponder strains. Antigen-specific secondary proliferative responses restricted by allogeneic Ia molecules of the macrophages were obtained in all strain combinations tested. These data indicate that Ir gene-controlled nonresponsiveness cannot be the result of a failure of antigen presentation.

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