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. 1981 Jul;7(4):435-43.
doi: 10.1007/BF01542988.

A human cell-surface antigen defined by a monoclonal antibody and controlled by a gene on chromosome 12

P W Andrews, B B Knowles, P N Goodfellow

A human cell-surface antigen defined by a monoclonal antibody and controlled by a gene on chromosome 12

P W Andrews et al. Somatic Cell Genet. 1981 Jul.

Abstract

A murine monoclonal antibody 602-29, subclass IgG1, that recognizes an antigenic determinant expressed by most human cells is described. Immunoprecipitation and sodium dodecyl sulfate-gel electrophoresis analysis indicate that the antigenic determinant is carried by a protein with an apparent molecular weight of 21,000. The antigen is expressed by human-mouse somatic cell hybrids, and analysis of segregants that have lost human chromosomes indicates that the gene controlling expression of the 602-29 antigen is on chromosome 12.

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