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. 1981 Sep 21;293(2):133-8.

[Changes in the female gonads of the chick embryo after tamoxifen]

[Article in French]
B Salzgeber, M Reyss-Brion, E E Baulieu
  • PMID: 6794863

[Changes in the female gonads of the chick embryo after tamoxifen]

[Article in French]
B Salzgeber et al. C R Seances Acad Sci III. .

Abstract

Tamoxifen has been given to Chick embryos between the 3rd and 7th day at doses of 0.2-2 mg/egg. It was non-toxic and strongly anti-estrogenic. The female gonads were modified in their development. The ovary showed dense medulla with numerous cords and a reduced cortex. The right gonad partially regressed and was "masculinized". Mullerian ducts normally regressed in tamoxifen-treated male embryos. These results suggest the physiological intervention of estrogen during the normal embryonic female development.

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