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. 1981 Oct;44(2):257-63.

Three monoclonal immunoglobulins, an IgG2(kappa), an IgM(kappa) and an IgM/A hybrid, in one patient. I. Isolation and characterization

E Tung, T K Kuan, G W Litman, A C Wang

Three monoclonal immunoglobulins, an IgG2(kappa), an IgM(kappa) and an IgM/A hybrid, in one patient. I. Isolation and characterization

E Tung et al. Immunology. 1981 Oct.

Abstract

Three monoclonal immunoglobulin components were identified in the plasma of a patient exhibiting a multiple gammopathy. These were an IgG2(κ) and IgM(κ) and an IgM/A hybrid molecule containing mu, alpha, and kappa antigenic determinants. This is the first report of an immunoglobulin hybrid which consists of portions of two different heavy-chain classes, and the significance of this observation in terms of our present concept of immunoglobulin gene arrangement is discussed.

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References

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