Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1981;33(5):541-4.
doi: 10.1007/BF02409486.

Effect of intraperitoneally injected fluoride on plasma calcium in suckling and adult rats

M J Larsen, A Richards, O Fejerskov

Effect of intraperitoneally injected fluoride on plasma calcium in suckling and adult rats

M J Larsen et al. Calcif Tissue Int. 1981.

Abstract

Sodium fluoride 10, 20 or 40 mg/kg body weight was given intraperitoneally to rats (6-11 days old and 90-95 days old). Blood analyses showed an initial increase in plasma fluoride concentration. The subsequent decrease in fluoride was paralleled by a decrease in total plasma calcium. These plasma concentrations were normal at blood collection 4 days after fluoride injection. The baby rats differed from the older rats in that their initial plasma calcium was higher and that the drop in plasma calcium concentration was less pronounced than in the old rats. A diet low in calcium and phosphate enhanced the effects of fluoride on total plasma calcium. The data indicate that the effect of large doses of fluoride on lowering the plasma calcium level is modified by the calcium intake.

PubMed Disclaimer

References

    1. J Lab Clin Med. 1962 Feb;59:195-210 - PubMed
    1. Arch Oral Biol. 1974 Aug;19(8):717-23 - PubMed
    1. Arch Oral Biol. 1979;24(2):123-30 - PubMed
    1. J Dent Res. 1964 Jan-Feb;43:50-6 - PubMed
    1. Calcif Tissue Res. 1977 May;22 Suppl:454-7 - PubMed