Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1982 Jan;79(1):36-40.
doi: 10.1073/pnas.79.1.36.

Conserved 5S rRNA complement to tRNA is not required for protein synthesis

B Pace, E A Matthews, K D Johnson, C R Cantor, N R Pace

Conserved 5S rRNA complement to tRNA is not required for protein synthesis

B Pace et al. Proc Natl Acad Sci U S A. 1982 Jan.

Abstract

The notion that tRNA and 5S rRNA interact through evolutionarily conserved complementary sequences has been tested by nucleolytic modification of the 5S rRNA, using the modified rRNA to reconstitute the large ribosomal subunit, and assaying for poly(uridylic acid)-directed polyphenylalanine synthesis. The 5S rRNA sequence C-G-A-A (residues 43-46) and several residues surrounding it are not essential for protein synthesis.

PubMed Disclaimer

References

    1. Science. 1967 Dec 29;158(3809):1695-9 - PubMed
    1. J Biol Chem. 1969 Nov 25;244(22):6241-53 - PubMed
    1. J Mol Biol. 1968 Jun 28;34(3):379-412 - PubMed
    1. Biochem Biophys Res Commun. 1973 Oct 1;54(3):942-8 - PubMed
    1. Anal Biochem. 1974 May;59(1):162-4 - PubMed

Publication types

LinkOut - more resources