Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1982 Apr;13(4):507-12.
doi: 10.1111/j.1365-2125.1982.tb01412.x.

The effect of acebutolol and propranolol on the hypoglycaemic action of glibenclamide

R Zaman, M J Kendall, P I Biggs

The effect of acebutolol and propranolol on the hypoglycaemic action of glibenclamide

R Zaman et al. Br J Clin Pharmacol. 1982 Apr.

Abstract

1 The effect of acebutolol, a relatively selective beta-adrenoceptor blocking drug and propranolol, a non-selective one, on the hypoglycaemic action of glibenclamide after an oral glucose load has been investigated in a group of maturity-onset diabetic patients. 2 Glibenclamide significantly reduced the blood glucose levels and both acebutolol and propranolol, at therapeutic doses, were found to modify this action significantly. 3 The effect of acebutolol was slightly less than that of propranolol. The difference was not statistically significant. 4 The modes of action of sulphonylureas are reviewed and it is suggested that beta-adrenoceptor blockers may modify their effect on insulin release. This appears to be a drug interaction rather than an effect of beta-adrenoceptor blockade on glucose tolerance.

PubMed Disclaimer

References

    1. Lancet. 1968 Apr 6;1(7545):749 - PubMed
    1. Arch Intern Med. 1969 Mar;123(3):314-22 - PubMed
    1. Lancet. 1970 Jan 10;1(7637):57-61 - PubMed
    1. Diabetologia. 1971 Jun;7(3):127-32 - PubMed
    1. Diabetologia. 1971 Aug;7(4):287-9 - PubMed

Publication types