Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1981 Jul;14(2-3):187-9.

Blockade of the inflammatory effects of platelet-activating factor by cyclo-oxygenase inhibitors

B B Vargaftig, S H Ferreira
  • PMID: 6802210

Blockade of the inflammatory effects of platelet-activating factor by cyclo-oxygenase inhibitors

B B Vargaftig et al. Braz J Med Biol Res. 1981 Jul.

Abstract

1. The edematogenic and hyperalgesic effects of synthetic Platelet-Activating Factor (PAF-acether) on the rat paw were investigated. 2. PAF-acether induced a dose-dependent oedema and hyperalgesia. 3. These effects were partially reduced by non-steroidal anti-inflammatory agents. 4. It is suggested that the oedema and hyperalgesia in response to PAF-acether are due at least in part to the release of a cyclo-oxygenase metabolite, probably prostacyclin.

PubMed Disclaimer

Publication types

MeSH terms