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. 1982 Jul 3;285(6334):20-1.
doi: 10.1136/bmj.285.6334.20.

Intestinal permeability in children with Crohn's disease and coeliac disease

A D Pearson, E J Eastham, M F Laker, A W Craft, R Nelson

Intestinal permeability in children with Crohn's disease and coeliac disease

A D Pearson et al. Br Med J (Clin Res Ed). .

Abstract

Mannitol and lactulose were used as probe molecules to measure intestinal permeability in children with active small-bowel Crohn's disease and with untreated coeliac disease. Mannitol and lactulose were administered by mouth in a moderately hypertonic solution (580 mmol (mosmol)/l), and results were expressed as the ratio of the molecules excreted in urine over five hours. Patients with Crohn's disease had a sixfold increase in permeability (due to increased lactulose permeability) and those with coeliac disease a fivefold increase (due to decreased mannitol permeability). From these results the test offers potential as a noninvasive investigation in children with small-bowel disease.

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