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Comparative Study
. 1978 Jul;19(7):587-92.
doi: 10.1136/gut.19.7.587.

Sialic acids of human large bowel mucosa: o-acylated variants in normal and malignant states

C M Rogers, K B Cooke, M I Filipe
Comparative Study

Sialic acids of human large bowel mucosa: o-acylated variants in normal and malignant states

C M Rogers et al. Gut. 1978 Jul.

Abstract

Five sialic acid variants have been demonstrated in normal, 'transitional', and tumour extracts of human large bowel mucosa by thin-layer chromatography. Two-dimensional thin-layer chromatography, with intermediate alkaline hydrolysis, confirmed that the variants were N-acetyl neuraminic acids with additional O-acylation. Cases studied so far show changes in the proportions of these variants in malignancy.

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References

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