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Comparative Study
. 1982 May 15;38(5):601-3.
doi: 10.1007/BF02327072.

Ergot alkaloids and phosphodiesterase; 'in vitro' activities in several rat brain areas

P Venutti, C Ferretti, P Portaleone
Comparative Study

Ergot alkaloids and phosphodiesterase; 'in vitro' activities in several rat brain areas

P Venutti et al. Experientia. .

Abstract

The 'in vitro' activity of ergotamine, dihydroergocristine, dihydroergocornine and dihydroergocryptine on the phosphodiesterase system at low and high Km in several rat brain areas was examined. These drugs were found to exert an inhibitory effect in all the areas examined with regard to both systems, and particularly on low substrate concentration phosphodiesterases.

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