Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1978 Jun;34(6):1077-81.

Cyclophosphamide-like cellular immunostimulation induced by 6-thioguanine (Lanvis)

H Van Dijk, G A Voermans

Cyclophosphamide-like cellular immunostimulation induced by 6-thioguanine (Lanvis)

H Van Dijk et al. Immunology. 1978 Jun.

Abstract

The possible immunostimulating effect of 6-thioguanine was studied in the mouse. It caused a dose-dependent suppression of the cellular and humoral immune response if administered 1 day before immunization. If, however, the interval between 6-thioguanine administration and immunization was extended to 5 days, a significant enhancement of delayed hypersensitivity was observed. The The enhancement occurred only after immunization with 10(6) and 10(7) sheep red cells. The analogy between the immunostimulating effects of 6-thioguanine and cyclophosphamide is discussed.

PubMed Disclaimer

References

    1. J Immunol Methods. 1976;12(3-4):261-5 - PubMed
    1. J Allergy Clin Immunol. 1975 Mar;55(3):145-51 - PubMed
    1. Cell Immunol. 1977 Mar 15;29(2):232-7 - PubMed
    1. Cell Immunol. 1976 Jul;25(1):8-14 - PubMed
    1. Nature. 1974 Oct 11;251(5475):550-1 - PubMed

LinkOut - more resources