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. 1982 Aug;70(2):470-3.
doi: 10.1172/jci110637.

Human lymphocytes with either the OKT4 or OKT8 phenotype produce interleukin 2 in culture

T A Luger, J S Smolen, T M Chused, A D Steinberg, J J Oppenheim

Human lymphocytes with either the OKT4 or OKT8 phenotype produce interleukin 2 in culture

T A Luger et al. J Clin Invest. 1982 Aug.

Abstract

In this study, we demonstrate that both highly purified T4+ and T8+ lymphocytes can produce substantial amounts of Interleukin 2(IL 2) when stimulated with the combination of concanavalin A (Con A) and phorbol myristate acetate. Furthermore, addition of IL 1 to macrophage-depleted T lymphocytes significantly increased IL 2 production by lymphocytes of either the T4+ or T8+ phenotype. These findings provide a basis for further studies of the molecular mechanisms involved in human immune cell interactions.

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