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. 1982 Mar;38(1):1-4.

Requirement of macrophage metabolic activity for T-lymphocyte activation

R Solana, M Santamaría, M de la Fuente, J Peña
  • PMID: 6808614

Requirement of macrophage metabolic activity for T-lymphocyte activation

R Solana et al. Rev Esp Fisiol. 1982 Mar.

Abstract

It has been recently demonstrated that macrophages are necessary accessory cells for T-lymphocyte activation by antigens, mitogens and allogenic cells. This paper shows the function of metabolically inactive macrophages in the activation of T-lymphocytes by phytohemagglutinin (PHA). Macrophages inactivated by mitomycin C are unable to collaborate with T-lymphocytes in the development of the proliferative response to PHA indicating that the role of the macrophage in T-lymphocyte activation by mitogens goes beyond insolubilizing it or rendering it more stimulatory by another passive mechanism.

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