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. 1982;8(2):189-92.
doi: 10.1007/BF00255482.

Pharmacokinetics of mitomycin C in rabbit and human

G A van Hazel, J S Kovach

Pharmacokinetics of mitomycin C in rabbit and human

G A van Hazel et al. Cancer Chemother Pharmacol. 1982.

Abstract

A sensitive and specific high-pressure liquid chromatographic assay was developed to characterize the plasma elimination and urinary excretion of mitomycin C in humans. Extraction of mitomycin C and an internal standard, porfiromycin, from plasma by chromatography over a non-ionic resin, Porapak Q, yields high recovery of both compounds and facilitates measurement of as little as 5 ng mitomycin C by reversed-phase high-pressure liquid chromatography. The assay was used to characterize the plasma elimination of mitomycin C in rabbits and was shown to be applicable to the characterization of the pharmacokinetics of mitomycin C in humans receiving as little as 8 mg/m2.

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