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. 1982;22(3):225-8.
doi: 10.1007/BF00545219.

Pinazepam: a precursor of N-desmethyldiazepam

G M Pacifici, G F Placidi, P Fornaro, R Gomeni

Pinazepam: a precursor of N-desmethyldiazepam

G M Pacifici et al. Eur J Clin Pharmacol. 1982.

Abstract

The plasma profile of a single oral dose of pinazepam 10 mg was studied in 6 healthy male volunteers, aged 26 to 31 years. The concentrations of the parent compound and of its metabolite in plasma were measured by gas-chromatography. The peak plasma levels of pinazepam was 36.8 +/- 5.1 ng/ml and of N-desmethyldiazepam 150 +/- 13.3 ng/ml. The plasma concentration of the metabolite become higher than that of the parent compound shortly after administration, suggesting that pinazepam acts as a prodrug.

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