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. 1982 Sep;57(9):681-4.
doi: 10.1136/adc.57.9.681.

Valproic acid and immune thrombocytopenia

R D Barr, S A Copeland, M L Stockwell, N Morris, J C Kelton

Valproic acid and immune thrombocytopenia

R D Barr et al. Arch Dis Child. 1982 Sep.

Abstract

During the course of a prospective serial study over a period of one year, findings compatible with immune-mediated thrombocytolysis accompanied the administration of valproic acid in about half of 45 children with epilepsy. Thrombocytopenia occurred in 15 and neutropenia in 12 patients, but was transient and self-limiting in each. The association is probably one of cause and effect, and it may reflect the structural similarity between valproic acid and constituents of cell membranes.

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References

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