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. 1982 Aug 23;31(8):731-7.
doi: 10.1016/0024-3205(82)90698-1.

The effect of a benzodiazepine antagonist, RO15-1788, in diazepam dependent rats

L F McNicholas, W R Martin

The effect of a benzodiazepine antagonist, RO15-1788, in diazepam dependent rats

L F McNicholas et al. Life Sci. .

Abstract

A benzodiazepine antagonist, RO15-1788, was administered intragastrically to diazepam-dependent gastric fistula rats and a precipitated abstinence syndrome was observed. The intensity of the RO15-1788 precipitated abstinence syndrome, calculated by the Precipitated Abstinence Scale, increased in intensity in a log-dose manner over a dose range of 1.0 to 15.0 mg/kg of RO15-1788 and plateaued at the 15.0 mg/kg dose. The RO15-1788 precipitated diazepam abstinence syndrome differed both qualitatively and quantitatively from the diazepam withdrawal syndrome.

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