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. 1982;77(4):376-8.
doi: 10.1007/BF00432774.

The presence of 7-hydroxychlorpromazine in CSF of chloropromazine-treated patients

G Alfredsson, M Lindberg, G Sedvall

The presence of 7-hydroxychlorpromazine in CSF of chloropromazine-treated patients

G Alfredsson et al. Psychopharmacology (Berl). 1982.

Abstract

7-Hydroxychlorpromazine (7-OHCPZ) has been identified and quantified in CSF from chlorpromazine (CPZ)-treated schizophrenic patients. The level of the metabolite in CSF was similar to that of CPZ. In serum the amount of 7-OHCPZ was about 30% of CPZ. The concentration of 7-OHCPZ in csf was positively and significantly correlated to the serum level.

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