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. 1982 Aug-Sep;64(8-9):577-80.
doi: 10.1016/s0300-9084(82)80090-4.

AP sites and AP endonucleases

L Grossman, R Grafstrom

AP sites and AP endonucleases

L Grossman et al. Biochimie. 1982 Aug-Sep.

Abstract

The sensitivity of internal and terminal apurinic/apyrimidinic (AP) sites to alkaline hydrolysis and beta-elimination is described. The symmetric and asymmetric modes of endonucleolytic hydrolysis by specific AP endonucleases are compared and the discrimination between their non-enzymatic and catalytic mechanism is discussed.

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