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Comparative Study
. 1982 Sep;44(3):339-42.
doi: 10.1016/0021-9150(82)90008-9.

Comparative effect of lipoxygenase products of arachidonic acid on rat aortic smooth muscle cell migration

J Nakao, T Ooyama, H Ito, W C Chang, S Murota
Comparative Study

Comparative effect of lipoxygenase products of arachidonic acid on rat aortic smooth muscle cell migration

J Nakao et al. Atherosclerosis. 1982 Sep.

Abstract

We investigated the effects of mono-hydroxyeicosatetraenoic acids (HETEs) and N-formyl-methionyl-leucyl-phenylalanine (F-Met-Leu-Phe) on rat aortic smooth muscle cell migration in modified Boyden chambers. 12-HETE showed the most potent stimulatory effect on smooth muscle cell migration among the mono-HETEs tested. The optimal concentrations for cell migration were 3 X 10(-15) and 3 X 10(-13) g/ml for 12-HETE and 10(-8) g/ml for 15-HETE, 5-HETE and F-Met-Leu-Phe were inactive with these cells. As 12-HETE is biosynthesized from arachidonic acid by the 12-lipoxygenase pathway in platelets and macrophages, and 15-HETE by the 15-lipoxygenase pathway in granulocytes, the present results indicate an important role for such cells in the early phase of atherosclerosis.

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