Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1982 Nov;45(11):1033-6.
doi: 10.1136/jnnp.45.11.1033.

Effect of epoprostenol (prostacyclin, PGI2) on cerebral blood flow in man

M M Brown, H Pickles

Effect of epoprostenol (prostacyclin, PGI2) on cerebral blood flow in man

M M Brown et al. J Neurol Neurosurg Psychiatry. 1982 Nov.

Abstract

Cerebral blood flow has been measured using the non-invasive Xenon133 clearance technique in eight normal subjects during an infusion of epoprostenol (prostacyclin, PGI2) at a dose of 5 ng/kg/min. The results were compared with a control infusion of saline given in a balanced order. PGI2 was found to result in a reduction in cerebral blood flow of about 8%. PGI2 also caused a small drop in diastolic blood pressure and it is proposed that the fall in cerebral blood flow may have been the result of disturbed autoregulation. The findings suggest that the therapeutic use of PGI2 in patients with cerebral artery spasm would not be accompanied by undesirable intracerebral steal.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

References

    1. Nat New Biol. 1973 Oct 10;245(145):187-8 - PubMed
    1. Arch Int Pharmacodyn Ther. 1977 May;227(1):162-3 - PubMed
    1. Ann Neurol. 1978 May;3(5):377-83 - PubMed
    1. Br J Clin Pharmacol. 1979 Feb;7(2):139-47 - PubMed
    1. J Neurol Sci. 1979 Jan;40(1):53-63 - PubMed

Publication types

LinkOut - more resources