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. 1982 Dec;38(3):1296-8.
doi: 10.1128/iai.38.3.1296-1298.1982.

Loss of virulence associated with absence of flagellum in an isogenic mutant of Pseudomonas aeruginosa in the burned-mouse model

T C Montie, D Doyle-Huntzinger, R C Craven, I A Holder

Loss of virulence associated with absence of flagellum in an isogenic mutant of Pseudomonas aeruginosa in the burned-mouse model

T C Montie et al. Infect Immun. 1982 Dec.

Abstract

To test the importance of flagella as a virulence factor, virulent strain Pseudomonas aeruginosa M-2 was mutagenized, and a Fla mutant was isolated. An M-2 Fla spontaneous motile revertant was isolated from M-2 Fla. The three strains were biochemically and morphologically identical. Assay of Fla in the burned-mouse model showed a severe loss of virulence. The Fla revertant was fully virulent. The importance of P. aeruginosa motility (flagella) for virulence in burns infections is indicated.

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