Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1978 Jun 1;147(6):1832-7.
doi: 10.1084/jem.147.6.1832.

Secretory component of epithelial cells is a surface receptor for polymeric immunoglobulins

S S Crago, R Kulhavy, S J Prince, J Mestecky

Secretory component of epithelial cells is a surface receptor for polymeric immunoglobulins

S S Crago et al. J Exp Med. .

Abstract

Epithelial cells of human fetal intestines and of a colonic carcinoma cell line (HT-29) exhibited intracellular and surface binding of polymeric immunoglobulins of IgA and IgM classes; monomeric IgA and IgG did not bind to these cells. Secretory component was identified as the receptor involved in the immunoglobulin binding. This conclusion was confirmed by the following experiments: trypsin abrogated the surface binding of polymeric immunoglobulin, reappearance of surface secretory component (SC) restored immunoglobulin binding; the appearance of SC in developing fetal tissues coincided with their potential to bind polymeric immunoglobulin; anti-SC reagents inhibited the binding of immunoglobulins to epithelial cells; and SC-containing secretory IgA did not bind to the surface of HT-29 cells.

PubMed Disclaimer

References

    1. Clin Exp Immunol. 1976 Jul;25(1):50-8 - PubMed
    1. Ciba Found Symp. 1977 Apr 26-28;(46):77-113 - PubMed
    1. Clin Immunol Immunopathol. 1977 Nov;8(3):475-86 - PubMed
    1. J Lab Clin Med. 1977 May;89(5):919-27 - PubMed
    1. Gastroenterology. 1977 Dec;73(6):1333-9 - PubMed

Publication types