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Comparative Study
. 1982;34(6):539-41.
doi: 10.1007/BF02411300.

Effect of the administration of 1,25-dihydroxyvitamin D3 on serum levels of 25-hydroxyvitamin D in postmenopausal osteoporosis

Comparative Study

Effect of the administration of 1,25-dihydroxyvitamin D3 on serum levels of 25-hydroxyvitamin D in postmenopausal osteoporosis

F Loré et al. Calcif Tissue Int. 1982.

Abstract

Serum concentrations of 25-hydroxyvitamin D were measured in a group of women with symptomatic postmenopausal osteoporosis, before and after long-term treatment with physiological doses of 1,25-dihydroxyvitamin D3. A competitive protein binding assay was used, which included a chromatographic step. The treatment resulted in a significant decrease in serum 25-hydroxyvitamin D levels that were higher than normal in basal conditions, the mean values before and after therapy being 27.7 ng/ml (+/- 17.1 SD) and 19.7 ng/ml (+/- 12.7), respectively. These findings seem to confirm the hypothesis that an inadequate product-inhibition of liver 25-hydroxylase is responsible for the increased basal levels of 25-hydroxyvitamin D found in postmenopausal osteoporosis.

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References

    1. Clin Chim Acta. 1974 Jul 31;54(2):235-42 - PubMed
    1. J Clin Invest. 1979 Sep;64(3):729-36 - PubMed
    1. Acta Med Scand. 1963 May;173:613-7 - PubMed
    1. Calcif Tissue Int. 1981;33(5):467-70 - PubMed
    1. Clin Endocrinol (Oxf). 1979 Jul;11(1):99-103 - PubMed

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