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. 1982 Sep;31(9):789-94.
doi: 10.2337/diab.31.9.789.

The effect of aldose reductase inhibition on motor nerve conduction velocity in diabetic rats

D K Yue, M A Hanwell, P M Satchell, J R Turtle

The effect of aldose reductase inhibition on motor nerve conduction velocity in diabetic rats

D K Yue et al. Diabetes. 1982 Sep.

Abstract

This study examined the effects of an aldose reductase inhibitor (CP 45634, Sorbinil, Pfizer, New York, New York) on the neuropathy of streptozotocin-induced diabetic rats. Sorbinil treatment for 4 wk reduced sciatic nerve sorbitol concentration and improved motor nerve conduction velocity in diabetes of 2-9 mo duration. It remains to be determined whether Sorbinil can prevent chronic diabetic neuropathy.

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