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Comparative Study
. 1982 Oct;3(3):197-200.
doi: 10.1007/BF02043309.

Comparison of the effectiveness of several formulations of sodium valproate: tablets, enteric-coated capsules, solutions and rectal capsules

D Battino, M Biraghi, C Cusi, A Nespolo, G Avanzini
Comparative Study

Comparison of the effectiveness of several formulations of sodium valproate: tablets, enteric-coated capsules, solutions and rectal capsules

D Battino et al. Ital J Neurol Sci. 1982 Oct.

Abstract

The effects of an oral enteric-coated preparation (VAL 579 capsules) of sodium valproate (VPA) were compared with those of conventional oral and rectal preparations in 24 epileptic patients. Enteric-coated capsules are useful for avoiding gastric intolerance to VPA. Plasma VPA level peaks after the enteric- coated form were later than after other forms. The bioavailability appeared to be the same for all the forms.

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References

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