Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1982;2(3):107-11.
doi: 10.1007/BF00541162.

Altered thiol status in patients with rheumatoid arthritis

J C Banford, D H Brown, R A Hazelton, C J McNeil, W E Smith, R D Sturrock

Altered thiol status in patients with rheumatoid arthritis

J C Banford et al. Rheumatol Int. 1982.

Abstract

The thiol status of patients with rheumatoid arthritis is significantly different from that of controls. Plasma thiol levels are lower, albumin thiol reactivity is altered and intracellular thiol levels measured after hemoglobin precipitation are increased. These variations correlate with other indices of disease severity and are one measure of a disturbance in the degree of oxidation of the blood. Penicillamine, in common with other effective therapeutic agents, produces an increase in serum thiol concentration. It causes a greater effect on serum thiol reactivity than other drugs and in particular it increases 'fast reacting' thiol levels without significantly altering the 'slow reacting' thiol level.

PubMed Disclaimer

References

    1. Clin Chim Acta. 1975 Apr 16;60(2):237-47 - PubMed
    1. J Pharm Pharmacol. 1980 Apr;32(4):301-2 - PubMed
    1. Metabolism. 1971 May;20(5):446-55 - PubMed
    1. Ann Intern Med. 1964 Sep;61:423-34 - PubMed
    1. Ann Rheum Dis. 1979 Apr;38(2):174-6 - PubMed

LinkOut - more resources