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. 1982 Oct;79(19):5961-5.
doi: 10.1073/pnas.79.19.5961.

Mismatch repair, gene conversion, and crossing-over in two recombination-defective mutants of Drosophila melanogaster

A T Carpenter

Mismatch repair, gene conversion, and crossing-over in two recombination-defective mutants of Drosophila melanogaster

A T Carpenter. Proc Natl Acad Sci U S A. 1982 Oct.

Abstract

Recombination-defective mutants at two loci that are known to decrease drastically the frequency of meiotic crossing-over do not decrease the frequency of gene conversion at the rosy locus. mei-9 mutant alleles produce frequent postmeiotic segregants manifested as mosaic progeny whereas controls and mei-218 mutants produce none. It is concluded that (i) recombination in Drosophila involves a biparental DNA intermediate and (ii) correction of heteroduplex DNA or recognition of biparental DNA or both is necessary, but not sufficient, for this intermediate to result in crossing-over of flanking markers. It is therefore likely, at least in Drosophila, that the isomerization step in Meselson-Radding type molecular models of recombination is under genetic control.

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References

    1. Proc Natl Acad Sci U S A. 1981 Dec;78(12):7648-51 - PubMed
    1. Proc Natl Acad Sci U S A. 1979 Mar;76(3):1377-81 - PubMed
    1. Annu Rev Genet. 1976;10:53-134 - PubMed
    1. Proc Natl Acad Sci U S A. 1975 Aug;72(8):3186-9 - PubMed
    1. Proc Natl Acad Sci U S A. 1976 Nov;73(11):4140-4 - PubMed

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