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Comparative Study
. 1982 Oct;79(19):6056-9.
doi: 10.1073/pnas.79.19.6056.

Similarity of secretory protein I from parathyroid gland to chromogranin A from adrenal medulla

D V Cohn, R Zangerle, R Fischer-Colbrie, L L Chu, J J Elting, J W Hamilton, H Winkler
Comparative Study

Similarity of secretory protein I from parathyroid gland to chromogranin A from adrenal medulla

D V Cohn et al. Proc Natl Acad Sci U S A. 1982 Oct.

Abstract

We have compared the amino acid and carbohydrate compositions, partial amino acid sequences, immunological crossreactivity, and physical properties of secretory protein I of the parathyroid gland and chromogranin A of adrenal gland. This comparison indicates that these proteins are similar molecules. Because secretory protein I is present in secretory granules containing parathormone and is cosecreted with the hormone, and because chromogranin A is contained within chromaffin granules and, likewise, is secreted with the catecholamines, the present observations raise the possibility that this class of protein plays a general role in hormone secretion or storage mechanisms.

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