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. 1980;2(3):325-48.
doi: 10.3109/08923978009046465.

Cytostatic effects of activated macrophages on tumor target cells: inhibition of cytotoxic action of ARA-C

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Cytostatic effects of activated macrophages on tumor target cells: inhibition of cytotoxic action of ARA-C

J L Krahenbuhl et al. J Immunopharmacol. 1980.

Abstract

Studies carried out to explore further the cytotoxic effects of activated macrophages from mice treated with Corynebacterium parvum revealed that their effect on the EMT-6 line of tumor target cells was limited solely to cytostasis with no evidence of a cytocidal effect. In additional studies, the cytostatic effects of activated macrophages markedly reduced the cytotoxic effects of the chemotherapeutic agent cytosine arabinoside on EMT-6 target cells.

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