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. 1983 Feb;71(2):385-9.
doi: 10.1172/jci110780.

Diagnosis of Bernard-Soulier syndrome and Glanzmann's thrombasthenia with a monoclonal assay on whole blood

R R Montgomery, T J Kunicki, C Taves, D Pidard, M Corcoran

Diagnosis of Bernard-Soulier syndrome and Glanzmann's thrombasthenia with a monoclonal assay on whole blood

R R Montgomery et al. J Clin Invest. 1983 Feb.

Abstract

Two hereditary platelet disorders, Bernard-Soulier syndrome and Glanzmann's thrombasthenia, are characterized by selective deficiencies of platelet membrane glycoproteins. Murine monoclonal antibodies were developed against platelet membrane glycoprotein Ib and against the glycoprotein IIb/IIIa complex. A rapid whole blood assay for the deficiency of these glycoproteins was developed and used to study whole blood samples from six patients with Glanzmann's thrombasthenia and three patients with Bernard-Soulier syndrome. Patients with type I and type II Glanzmann's thrombasthenia were easily detectable with this assay. This permits the diagnosis of these disorders on 200 microliters of whole blood within 2 h of blood sampling.

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References

    1. Br J Haematol. 1974 Oct;28(2):253-60 - PubMed
    1. J Clin Invest. 1978 Sep;62(3):716-9 - PubMed
    1. J Lab Clin Med. 1979 Apr;93(4):652-60 - PubMed
    1. Semin Hematol. 1979 Jul;16(3):234-50 - PubMed
    1. J Clin Invest. 1980 Dec;66(6):1311-8 - PubMed

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