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. 1983 Feb 1;157(2):807-12.
doi: 10.1084/jem.157.2.807.

Macrophage activation selectively enhances expression of Fc receptors for IgG2a

R A Ezekowitz, M Bampton, S Gordon

Macrophage activation selectively enhances expression of Fc receptors for IgG2a

R A Ezekowitz et al. J Exp Med. .

Abstract

After infection with bacillus Calmette-Guérin, peritoneal macrophages (Mø) display enhanced expression of FcR for both monomeric and complexed IgG2a, but not IgG2b. Isotype specificity of FcR can be reversed on nonactivated Mø by immune lymphokines, and IgG2a immune complexes are more effective triggers of the respiratory burst in activated Mø. Selective enhancement of IgG2a FcR by Mø activation could account for efficacy of homologous ab in mediating cytotoxicity in some systems.

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References

    1. J Clin Invest. 1975 Oct;56(4):1035-42 - PubMed
    1. J Exp Med. 1975 Dec 1;142(6):1520-33 - PubMed
    1. J Immunol Methods. 1976;10(4):301-6 - PubMed
    1. J Exp Med. 1977 Dec 1;146(6):1648-62 - PubMed
    1. J Immunol. 1978 Oct;121(4):1329-33 - PubMed

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