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. 1983 Feb 25;219(4587):975-7.
doi: 10.1126/science.6823559.

Transfusions of whole blood prevent spontaneous diabetes mellitus in the BB/W rat

A A Rossini, J P Mordes, A M Pelletier, A A Like

Transfusions of whole blood prevent spontaneous diabetes mellitus in the BB/W rat

A A Rossini et al. Science. .

Abstract

Weekly transfusions of whole blood from a nondiabetic subline of BB/W rats reduced the incidence of diabetes in susceptible BB/W rats from 39 to 0 percent and the incidence of pancreatic insulitis from 64 to 6 percent. Responsiveness of lymphocytes to concanavalin A was found to be low in rats with diabetes or insulitis. Transfusion restored concanavalin A responsiveness to levels observed in control rats free of diabetes or insulitis. These data suggest that whole blood alters the course of autoimmune BB/W rat diabetes.

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