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Clinical Trial
. 1983;15 Suppl 2(Suppl 2):255S-259S.
doi: 10.1111/j.1365-2125.1983.tb05873.x.

Mianserin, maprotiline and the electroencephalogram

E M Sedgwick, J G Edwards
Clinical Trial

Mianserin, maprotiline and the electroencephalogram

E M Sedgwick et al. Br J Clin Pharmacol. 1983.

Abstract

1 EEGs were recorded from patients with depressive illness before and after four weeks of treatment with mianserin, maprotiline or placebo. 2 Visual analysis of the records showed a small but statistically significant increase in frequency of beta activity in the mianserin group. 3 One subject taking maprotiline developed spike and wave discharges but had no convulsive seizures. 4 The findings do not support those of previous studies. It seems that changes seen in the EEG early after treatment are not sustained for four weeks.

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